AustralieFrV1, Main, Exploration, bibRecord, 003624

Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women

Identifieur interne : 003624 ( Main/Exploration ); précédent : 003623; suivant : 003625

Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women

Auteurs : Myrto Barrdahl ; Federico Canzian [Allemagne] ; Amit D. Joshi [États-Unis] ; Ruth C. Travis [Royaume-Uni] ; Jenny Chang-Claude ; Paul L. Auer [États-Unis] ; Susan M. Gapstur [États-Unis] ; Mia Gaudet [États-Unis] ; W. Ryan Diver [États-Unis] ; Brian E. Henderson [États-Unis] ; Christopher A. Haiman [États-Unis] ; Fredrick R. Schumacher [États-Unis] ; Loïc Le Marchand [États-Unis] ; Christine D. Berg [États-Unis] ; Stephen J. Chanock [États-Unis] ; Robert N. Hoover [États-Unis] ; Anja Rudolph ; Regina G. Ziegler [États-Unis] ; Graham G. Giles [Australie] ; Laura Baglietto [Australie] ; Gianluca Severi [Australie] ; Susan E. Hankinson [États-Unis] ; Sara Lindström [États-Unis] ; Walter Willet [États-Unis] ; David J. Hunter [États-Unis] ; Julie E. Buring [États-Unis] ; I-Min Lee [États-Unis] ; Shumin Zhang [États-Unis] ; Laure Dossus [France] ; David G. Cox [Royaume-Uni, France] ; Kay-Tee Khaw [Royaume-Uni] ; Eiliv Lund [Norvège] ; Alessio Naccarati [Italie] ; Petra H. Peeters [Royaume-Uni, Pays-Bas] ; J. Ram N Quir S [Espagne] ; Elio Riboli [Royaume-Uni] ; Malin Sund [Suède] ; Dimitrios Trichopoulos [États-Unis, Grèce] ; Ross L. Prentice [États-Unis] ; Peter Kraft [États-Unis] ; Rudolf Kaaks ; Daniele Campa

Source :

Human Molecular Genetics [ 0964-6906 ] ; 2014.

RBID : PMC:4159150

Descripteurs français

KwdFr :
- Allèles, Cartographie chromosomique, Femelle, Génotype, Humains, Interaction entre gènes et environnement, Marqueurs biologiques tumoraux, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Risque, Tumeurs du sein (épidémiologie), Tumeurs du sein (étiologie), Étude d'association pangénomique, Études cas-témoins.
MESH :
- épidémiologie : Tumeurs du sein.
- étiologie : Tumeurs du sein.
- Allèles, Cartographie chromosomique, Femelle, Génotype, Humains, Interaction entre gènes et environnement, Marqueurs biologiques tumoraux, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Risque, Étude d'association pangénomique, Études cas-témoins.

English descriptors

KwdEn :
- Alleles, Biomarkers, Tumor, Breast Neoplasms (epidemiology), Breast Neoplasms (etiology), Case-Control Studies, Chromosome Mapping, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, Risk.
MESH :
- chemical : Biomarkers, Tumor.
- epidemiology : Breast Neoplasms.
- etiology : Breast Neoplasms.
- Alleles, Case-Control Studies, Chromosome Mapping, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, Risk.

Abstract

We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case–control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case–case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and SLC4A7-rs4973768 (P_interaction = 8.84 × 10⁻⁴) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and SLC4A7-rs4973768 that if further replicated could help our understanding in the etiology of BC.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159150

DOI: 10.1093/hmg/ddu223
PubMed: 24895409
PubMed Central: 4159150

Affiliations:

Allemagne, Australie, Espagne, France, Grèce, Italie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women</title>
<author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Genomic Epidemiology Group</addr-line>
,<institution>German Cancer Research Center (DKFZ)</institution>
,<addr-line>Heidelberg D-69120</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D." last="Joshi">Amit D. Joshi</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Cancer Epidemiology Unit</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LF</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Public Health Sciences Division</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>School of Public Health</addr-line>
,<institution>University of Wisconsin</institution>
,<addr-line>Milwaukee, WI 1240</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia" sort="Gaudet, Mia" uniqKey="Gaudet M" first="Mia" last="Gaudet">Mia Gaudet</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Cancer Center</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D." last="Berg">Christine D. Berg</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Faculty of Medicine</addr-line>
,<institution>Monash University</institution>
,<addr-line>Melbourne, VIC 3800</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Channing Division of Network Medicine</addr-line>
,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Biostatistics and Epidemiology</addr-line>
,<institution>University of Massachusetts</institution>
,<addr-line>Amherst, MA 01003-9304</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willet, Walter" sort="Willet, Walter" uniqKey="Willet W" first="Walter" last="Willet">Walter Willet</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Shumin" sort="Zhang, Shumin" uniqKey="Zhang S" first="Shumin" last="Zhang">Shumin Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>INSERM, Centre for Research in Epidemiology and Population Health</addr-line>
,<institution>Institut Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
<addr-line>F-94805</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af17"><institution>Paris South University</institution>
,<addr-line>Villejuif</addr-line>
<addr-line>F-94807</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><institution>Université de Lyon, Université Lyon 1, ISPB</institution>
,<addr-line>Lyon</addr-line>
<addr-line>F-69007</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af20"><addr-line>INSERM U1052</addr-line>
,</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>CNRS UMR5286</addr-line>
,<institution>Centre de Recherche en Cancérologie de Lyon</institution>
,<addr-line>Lyon F-69008</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>Centre Léon Bérard</institution>
,<addr-line>Lyon F-69008</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Public Health and Primary Care, School of Clinical Medicine</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge CB2 0SP</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Institute of Community Medicine</addr-line>
,<institution>University of Tromsø</institution>
,<addr-line>Tromsø N-9037</addr-line>
,<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular and Genetic Epidemiology Unit</addr-line>
,<institution>Human Genetics Foundation Torino</institution>
,<addr-line>Torino I-10126</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Epidemiology, Julius Center for Health Sciences and Primary Care</addr-line>
,<institution>University Medical Center</institution>
,<addr-line>Utrecht 3584 CS</addr-line>
,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Public Health Directorate</institution>
,<addr-line>Asturias ES-CP33006</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
<affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Department of Surgical and Perioperative Sciences, Surgery</addr-line>
,<institution>Umeå University</institution>
,<addr-line>Umeå S-90185</addr-line>
,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Bureau of Epidemiologic Research</addr-line>
,<institution>Academy of Athens</institution>
,<addr-line>Athens 10679</addr-line>
,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af30"><institution>Hellenic Health Foundation</institution>
,<addr-line>Athens 11527</addr-line>
,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Public Health Sciences Division</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24895409</idno>
<idno type="pmc">4159150</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159150</idno>
<idno type="RBID">PMC:4159150</idno>
<idno type="doi">10.1093/hmg/ddu223</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001871</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001871</idno>
<idno type="wicri:Area/Pmc/Curation">001731</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001731</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001403</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001403</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003405</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003405</idno>
<idno type="wicri:Area/PubMed/Curation">003293</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003293</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003293</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003293</idno>
<idno type="wicri:Area/Ncbi/Merge">001A94</idno>
<idno type="wicri:Area/Ncbi/Curation">001A94</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001A94</idno>
<idno type="wicri:doubleKey">0964-6906:2014:Barrdahl M:post:gwas:gene</idno>
<idno type="wicri:Area/Main/Merge">003643</idno>
<idno type="wicri:Area/Main/Curation">003624</idno>
<idno type="wicri:Area/Main/Exploration">003624</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women</title>
<author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Genomic Epidemiology Group</addr-line>
,<institution>German Cancer Research Center (DKFZ)</institution>
,<addr-line>Heidelberg D-69120</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D." last="Joshi">Amit D. Joshi</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Cancer Epidemiology Unit</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LF</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Public Health Sciences Division</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>School of Public Health</addr-line>
,<institution>University of Wisconsin</institution>
,<addr-line>Milwaukee, WI 1240</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia" sort="Gaudet, Mia" uniqKey="Gaudet M" first="Mia" last="Gaudet">Mia Gaudet</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology</addr-line>
,<institution>American Cancer Society</institution>
,<addr-line>Atlanta, GA 30303</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><addr-line>Department of Preventive Medicine, Keck School of Medicine</addr-line>
,<institution>University of Southern California</institution>
,<addr-line>Los Angeles, CA 90033</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Cancer Center</addr-line>
,<institution>University of Hawaii</institution>
,<addr-line>Honolulu, HI 96813</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D." last="Berg">Christine D. Berg</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Division of Cancer Epidemiology and Genetics</addr-line>
,<institution>National Cancer Institute</institution>
,<addr-line>Bethesda, MD 20892</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><addr-line>Faculty of Medicine</addr-line>
,<institution>Monash University</institution>
,<addr-line>Melbourne, VIC 3800</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Cancer Epidemiology Centre Melbourne</addr-line>
,<institution>Cancer Council Victoria</institution>
,<addr-line>Carlton South, VIC 3004</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health</addr-line>
,<institution>The University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
<addr-line>, VIC 3010</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Channing Division of Network Medicine</addr-line>
,<institution>Brigham and Women's Hospital and Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Division of Biostatistics and Epidemiology</addr-line>
,<institution>University of Massachusetts</institution>
,<addr-line>Amherst, MA 01003-9304</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Willet, Walter" sort="Willet, Walter" uniqKey="Willet W" first="Walter" last="Willet">Walter Willet</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Shumin" sort="Zhang, Shumin" uniqKey="Zhang S" first="Shumin" last="Zhang">Shumin Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>INSERM, Centre for Research in Epidemiology and Population Health</addr-line>
,<institution>Institut Gustave Roussy</institution>
,<addr-line>Villejuif</addr-line>
<addr-line>F-94805</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af17"><institution>Paris South University</institution>
,<addr-line>Villejuif</addr-line>
<addr-line>F-94807</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><institution>Université de Lyon, Université Lyon 1, ISPB</institution>
,<addr-line>Lyon</addr-line>
<addr-line>F-69007</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="af20"><addr-line>INSERM U1052</addr-line>
,</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af21"><addr-line>CNRS UMR5286</addr-line>
,<institution>Centre de Recherche en Cancérologie de Lyon</institution>
,<addr-line>Lyon F-69008</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>Centre Léon Bérard</institution>
,<addr-line>Lyon F-69008</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<affiliation wicri:level="1"><nlm:aff id="af23"><addr-line>Department of Public Health and Primary Care, School of Clinical Medicine</addr-line>
,<institution>University of Cambridge</institution>
,<addr-line>Cambridge CB2 0SP</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Institute of Community Medicine</addr-line>
,<institution>University of Tromsø</institution>
,<addr-line>Tromsø N-9037</addr-line>
,<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Molecular and Genetic Epidemiology Unit</addr-line>
,<institution>Human Genetics Foundation Torino</institution>
,<addr-line>Torino I-10126</addr-line>
,<country>Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af26"><addr-line>Department of Epidemiology, Julius Center for Health Sciences and Primary Care</addr-line>
,<institution>University Medical Center</institution>
,<addr-line>Utrecht 3584 CS</addr-line>
,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>Public Health Directorate</institution>
,<addr-line>Asturias ES-CP33006</addr-line>
,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>School of Public Health</addr-line>
,<institution>Imperial College London</institution>
,<addr-line>London SW7 2AZ</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
<affiliation wicri:level="1"><nlm:aff id="af28"><addr-line>Department of Surgical and Perioperative Sciences, Surgery</addr-line>
,<institution>Umeå University</institution>
,<addr-line>Umeå S-90185</addr-line>
,<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Bureau of Epidemiologic Research</addr-line>
,<institution>Academy of Athens</institution>
,<addr-line>Athens 10679</addr-line>
,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af30"><institution>Hellenic Health Foundation</institution>
,<addr-line>Athens 11527</addr-line>
,<country>Greece</country>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Public Health Sciences Division</addr-line>
,<institution>Fred Hutchinson Cancer Research Center</institution>
,<addr-line>Seattle, WA 98109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Epidemiology</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name>
<affiliation><nlm:aff wicri:cut=" and" id="af1"><addr-line>Division of Cancer Epidemiology</addr-line>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term>
<term>Biomarkers, Tumor</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (etiology)</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term>
<term>Cartographie chromosomique</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Risque</term>
<term>Tumeurs du sein (épidémiologie)</term>
<term>Tumeurs du sein (étiologie)</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biomarkers, Tumor</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Case-Control Studies</term>
<term>Chromosome Mapping</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allèles</term>
<term>Cartographie chromosomique</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Marqueurs biologiques tumoraux</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Prédisposition génétique à une maladie</term>
<term>Risque</term>
<term>Étude d'association pangénomique</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNM stage, tumor grade, tumor size, age at diagnosis, estrogen receptor status and progesterone receptor status) as joint determinants of BC risk. We used a nested case–control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case–case comparisons for differential associations of polymorphisms by subgroups of the prognostic factors. We analyzed multiplicative interactions between the SNPs and the risk factors. Finally, we also performed a meta-analysis of the interaction ORs from BPC3 and the Breast Cancer Association Consortium. After correction for multiple testing, no significant interaction between the SNPs and the established risk factors in the BPC3 study was found. The meta-analysis showed a suggestive interaction between smoking status and <italic>SLC4A7</italic>
-rs4973768 (<italic>P</italic>
<sub>interaction</sub>
 = 8.84 × 10<sup>−4</sup>
) which, although not significant after considering multiple comparison, has a plausible biological explanation. In conclusion, in this study of up to almost 79 000 women we can conclusively exclude any novel major interactions between genome-wide association studies hits and the epidemiologic risk factors taken into consideration, but we propose a suggestive interaction between smoking status and <italic>SLC4A7</italic>
-rs4973768 that if further replicated could help our understanding in the etiology of BC.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
</list>
<tree><noCountry><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name>
<name sortKey="Campa, Daniele" sort="Campa, Daniele" uniqKey="Campa D" first="Daniele" last="Campa">Daniele Campa</name>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
</noRegion>
</country>
<country name="États-Unis"><noRegion><name sortKey="Joshi, Amit D" sort="Joshi, Amit D" uniqKey="Joshi A" first="Amit D." last="Joshi">Amit D. Joshi</name>
</noRegion>
<name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name>
<name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L." last="Auer">Paul L. Auer</name>
<name sortKey="Berg, Christine D" sort="Berg, Christine D" uniqKey="Berg C" first="Christine D." last="Berg">Christine D. Berg</name>
<name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W. Ryan" last="Diver">W. Ryan Diver</name>
<name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<name sortKey="Gaudet, Mia" sort="Gaudet, Mia" uniqKey="Gaudet M" first="Mia" last="Gaudet">Mia Gaudet</name>
<name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<name sortKey="Hankinson, Susan E" sort="Hankinson, Susan E" uniqKey="Hankinson S" first="Susan E." last="Hankinson">Susan E. Hankinson</name>
<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N." last="Hoover">Robert N. Hoover</name>
<name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
<name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name>
<name sortKey="Lee, I Min" sort="Lee, I Min" uniqKey="Lee I" first="I-Min" last="Lee">I-Min Lee</name>
<name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name>
<name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name>
<name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
<name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
<name sortKey="Willet, Walter" sort="Willet, Walter" uniqKey="Willet W" first="Walter" last="Willet">Walter Willet</name>
<name sortKey="Zhang, Shumin" sort="Zhang, Shumin" uniqKey="Zhang S" first="Shumin" last="Zhang">Shumin Zhang</name>
<name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G." last="Ziegler">Regina G. Ziegler</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
</noRegion>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name>
<name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name>
</country>
<country name="Australie"><noRegion><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
</noRegion>
<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
</country>
<country name="France"><noRegion><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
</noRegion>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<name sortKey="Cox, David G" sort="Cox, David G" uniqKey="Cox D" first="David G." last="Cox">David G. Cox</name>
<name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name>
</country>
<country name="Norvège"><noRegion><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
</noRegion>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
</noRegion>
</country>
<country name="Espagne"><noRegion><name sortKey="Quir S, J Ram N" sort="Quir S, J Ram N" uniqKey="Quir S J" first="J. Ram N" last="Quir S">J. Ram N Quir S</name>
</noRegion>
</country>
<country name="Suède"><noRegion><name sortKey="Sund, Malin" sort="Sund, Malin" uniqKey="Sund M" first="Malin" last="Sund">Malin Sund</name>
</noRegion>
</country>
<country name="Grèce"><noRegion><name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
</noRegion>
<name sortKey="Trichopoulos, Dimitrios" sort="Trichopoulos, Dimitrios" uniqKey="Trichopoulos D" first="Dimitrios" last="Trichopoulos">Dimitrios Trichopoulos</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003624 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003624 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4159150
   |texte=   Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24895409" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women

Post-GWAS gene–environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.